According to E-Mu - "All E-MU Digital Audio Systems and
USB 2.0 Interface products are considered to be UNSUPPORTED and not compatible with Vista until the official Vista drivers are released." So, when will your software/driver be supported? To find out, check out this Windows Vista Computability Matrix and Timeline. In addition to a schedule for software releases, the page also contains tutorials on how to tweak drivers and applications under Vista. For those who want to receive emails about driver/software announcements, the page has a link to an E-MU newsletter.