Checkout this great video interview with Ben Burtt, the sound designer for Pixar's latest film WALL-E. If you are not familiar with Ben Burtt, he's the sound designer who worked on huge films such as Star Wars, E.T. The Extra-Terrestrial, and Indiana Jones to name a few. I thought it was interesting he was using an Edirol Midi Controller and a light pen to trigger and modulate sounds. Also, his use of "found" sound to create unique cues is really creative.
I also dug up these links on the film: